REBody - User contributions [en]

Diagram:Map

2026-07-20T23:57:39Z

Technobaboo: Update diagram layout

{
"version": 2,
"allPages": true,
"category": "",
"pages": [
"ERα",
"ERβ",
"IGF-1",
"E2",
"T",
"Aromatase",
"IGF-1R",
"GR",
"Clobetasol",
"Dexras1",
"MAPK",
"PPAR-γ",
"Pioglitazone",
"CBD",
"FOXA1",
"GATA3",
"Breast Ductal Lengthening",
"EGFR",
"AREG",
"PI3K",
"Akt",
"CDK",
"Cyclin",
"Cell Division"
],
"view": {
"x": 775.3,
"y": -576.05,
"zoom": 1.063
},
"things": {
"AREG": {
"x": 469.96,
"y": -358.6,
"pinned": false
},
"Aromatase": {
"x": 54.08,
"y": -84,
"pinned": false
},
"Breast Ductal Lengthening": {
"x": 1613.56,
"y": -355.6,
"pinned": false
},
"CBD": {
"x": -216.95,
"y": -759.79,
"pinned": false
},
"Clobetasol": {
"x": -451.58,
"y": -511.67,
"pinned": false
},
"Dexras1": {
"x": 69.67,
"y": -506.79,
"pinned": false
},
"E2": {
"x": 175.3,
"y": -206.56,
"pinned": false
},
"EGFR": {
"x": 725.07,
"y": -360.59,
"pinned": false
},
"ERα": {
"x": 177.48,
"y": -356.62,
"pinned": false
},
"ERβ": {
"x": 174.23,
"y": -69.74,
"pinned": false
},
"FOXA1": {
"x": 550.77,
"y": -248.41,
"pinned": false
},
"GATA3": {
"x": 669.67,
"y": -246.7,
"pinned": false
},
"GR": {
"x": -218.11,
"y": -508.12,
"pinned": false
},
"IGF-1": {
"x": -377.56,
"y": -379.15,
"pinned": false
},
"IGF-1R": {
"x": -221.29,
"y": -381.29,
"pinned": false
},
"MAPK": {
"x": -33.87,
"y": -368.8,
"pinned": false
},
"Main Page": {
"x": -446.18,
"y": -780.94,
"pinned": false
},
"PPAR-γ": {
"x": -221.04,
"y": -605.44,
"pinned": false
},
"Pioglitazone": {
"x": -448.49,
"y": -608.03,
"pinned": false
},
"T": {
"x": -71.89,
"y": -196.58,
"pinned": false
},
"PI3K": {
"x": 727.39,
"y": -583.07,
"pinned": false
},
"Akt": {
"x": 1033.53,
"y": -582.39,
"pinned": false
},
"CDK": {
"x": 1428.76,
"y": -578.88,
"pinned": false
},
"Cyclin": {
"x": 1237.29,
"y": -581.99,
"pinned": false
},
"Cell Division": {
"x": 1611.88,
"y": -579.3,
"pinned": false
}
},
"edges": {
"E2#1": {
"hx": 177.25,
"hy": -259.7,
"hset": true,
"pinned": false
},
"E2#2": {
"hx": 169.85,
"hy": -136.69,
"hset": true,
"pinned": false
},
"ERβ#1": {
"hx": 317.05,
"hy": -215.89,
"hset": true,
"pinned": false
},
"MAPK#2": {
"hx": 19.97,
"hy": -294.75,
"hset": true,
"pinned": false
},
"ERβ#2": {
"hx": 980.31,
"hy": -27.56,
"hset": true,
"pinned": false
},
"ERβ#3": {
"hx": 969.97,
"hy": 47.68,
"hset": true,
"pinned": false
},
"GR#3": {
"hx": 428.62,
"hy": -1001.43,
"hset": true,
"pinned": false
}
}
}

GR

2026-07-20T22:57:11Z

Technobaboo: Update inference §3 (diagram)

{{#inference:id=1|to=Dexras1|tag=induces expression of}}<ref>{{cite web|url=https://www.nature.com/articles/srep28648|title=Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis|website=Nature|author=Hyo Jung Kim, et al.|quote=Previously, we showed that small G protein Dexras1 is expressed by glucocorticoids and leads to adipocyte differentiation}}</ref>

== References ==
<references />

{{#inference:id=3|to=CDK|tag=displaces ERα from|context=specifically CCND1/CDK2/CDK6, via FOXA1-primed chromatin sites}}<ref>{{cite web
|title=Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.
|author=Tonsing-Carter E; Hernandez KM; Kim CR; Harkless RV; Oh A; Bowie KR; West-Szymanski DC; Betancourt-Ponce MA; Green BD; Lastra RR; Fleming GF; Chandarlapaty S; Conzen SD
|date=2019 Jul 24
|publisher=Breast cancer research : BCR
|url=https://pubmed.ncbi.nlm.nih.gov/31340854/
|pmid=31340854
|quote=
}}</ref>

[[Category:Receptor]]

GR

2026-07-20T22:56:48Z

Technobaboo: Update inference §3 (diagram)

GR

2026-07-20T22:56:44Z

Technobaboo: Remove inference §2 (diagram)

GR

2026-07-20T22:56:36Z

Technobaboo: Update inference §2 (diagram)

GR

2026-07-20T22:56:23Z

Technobaboo: Add inference to CDK (displaces ERα from) (diagram)

{{#inference:id=1|to=Dexras1|tag=induces expression of}}<ref>{{cite web|url=https://www.nature.com/articles/srep28648|title=Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis|website=Nature|author=Hyo Jung Kim, et al.|quote=Previously, we showed that small G protein Dexras1 is expressed by glucocorticoids and leads to adipocyte differentiation}}</ref>

== References ==
<references />

{{#inference:id=2|to=Cyclin|tag=displaces ERα from|context=specifically CCND1/CDK2/CDK6, via FOXA1-primed chromatin sites}}<ref>{{cite web
|title=Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.
|author=Tonsing-Carter E; Hernandez KM; Kim CR; Harkless RV; Oh A; Bowie KR; West-Szymanski DC; Betancourt-Ponce MA; Green BD; Lastra RR; Fleming GF; Chandarlapaty S; Conzen SD
|date=2019 Jul 24
|publisher=Breast cancer research : BCR
|url=https://pubmed.ncbi.nlm.nih.gov/31340854/
|pmid=31340854
|quote=
}}</ref>

{{#inference:id=3|to=CDK|tag=displaces ERα from}}

[[Category:Receptor]]

GR

2026-07-20T22:55:40Z

Technobaboo: Update inference §2 (diagram)

{{#inference:id=1|to=Dexras1|tag=induces expression of}}<ref>{{cite web|url=https://www.nature.com/articles/srep28648|title=Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis|website=Nature|author=Hyo Jung Kim, et al.|quote=Previously, we showed that small G protein Dexras1 is expressed by glucocorticoids and leads to adipocyte differentiation}}</ref>

== References ==
<references />

{{#inference:id=2|to=Cyclin|tag=displaces ERα from|context=specifically CCND1/CDK2/CDK6, via FOXA1-primed chromatin sites}}<ref>{{cite web
|title=Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.
|author=Tonsing-Carter E; Hernandez KM; Kim CR; Harkless RV; Oh A; Bowie KR; West-Szymanski DC; Betancourt-Ponce MA; Green BD; Lastra RR; Fleming GF; Chandarlapaty S; Conzen SD
|date=2019 Jul 24
|publisher=Breast cancer research : BCR
|url=https://pubmed.ncbi.nlm.nih.gov/31340854/
|pmid=31340854
|quote=
}}</ref>

[[Category:Receptor]]

GR

2026-07-20T22:53:41Z

Technobaboo: Update inference §2 (diagram)

GR

2026-07-20T22:52:55Z

Technobaboo: Add inference to Cyclin (displaces ERα from) (diagram)

GR

2026-07-20T22:50:31Z

Technobaboo: Remove inference §2 (diagram)

GR

2026-07-20T22:49:23Z

Technobaboo: Add inference to ERα (reduces gene expression of) (diagram)

EGFR

2026-07-20T22:17:19Z

Technobaboo: Update inference §1 (diagram)

{{#inference:id=1|to=Breast Ductal Lengthening|tag=facilitates|inferred=yes}}<ref>{{cite web|url=https://doi.org/10.1073/pnas.0611647104|title=Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development|author=Laura Ciarloni; Sonia Mallepell; Cathrin Brisken|date=2007|quote=In fact, we find that estrogens induce amphiregulin through the ERα and require amphiregulin to induce proliferation of the mammary epithelium.}}</ref>

== References ==
<references />

{{#inference:id=2|to=PI3K|tag=activates|context=intracellular}}

[[Category:Receptor]]

Cell Division

2026-07-20T22:17:13Z

Technobaboo: Add inference to Breast Ductal Lengthening (drives) (diagram)

Cell Division

2026-07-20T22:17:10Z

Technobaboo: Remove inference §1 (diagram)

ERβ

2026-07-20T22:16:50Z

Technobaboo: Update inference §2 (diagram)

{{#inference:id=1|to=ERα|tag=inhibits}}

{{#inference:id=2|to=Cyclin|tag=reduces gene expression of|context=cyclin B}}

{{#inference:id=3|to=CDK|tag=reduces gene expression of}}

[[Category:Receptor]]
aka Estrogen Receptor Beta

see https://en.wikipedia.org/wiki/Estrogen_receptor_beta

ERβ

2026-07-20T22:16:48Z

Technobaboo: Update inference §3 (diagram)

{{#inference:id=1|to=ERα|tag=inhibits}}

{{#inference:id=2|to=Cyclin|tag=reduces gene expression of}}

{{#inference:id=3|to=CDK|tag=reduces gene expression of}}

[[Category:Receptor]]
aka Estrogen Receptor Beta

see https://en.wikipedia.org/wiki/Estrogen_receptor_beta

ERβ

2026-07-20T22:16:45Z

Technobaboo: Update inference §3 (diagram)

{{#inference:id=1|to=ERα|tag=inhibits}}

{{#inference:id=2|to=Cyclin|tag=reduces gene expression of}}

{{#inference:id=3|to=CDK|tag=reduces gene expression of|context=cyclin B}}

[[Category:Receptor]]
aka Estrogen Receptor Beta

see https://en.wikipedia.org/wiki/Estrogen_receptor_beta

ERβ

2026-07-20T22:15:25Z

Technobaboo: Add inference to CDK (reduces gene expression of) (diagram)

ERβ

2026-07-20T22:15:13Z

Technobaboo: Add inference to Cyclin (reduces gene expression of) (diagram)

{{#inference:id=1|to=ERα|tag=inhibits}}

{{#inference:id=2|to=Cyclin|tag=reduces gene expression of}}

[[Category:Receptor]]
aka Estrogen Receptor Beta

see https://en.wikipedia.org/wiki/Estrogen_receptor_beta

Cell Division

2026-07-20T22:11:28Z

Technobaboo: Add inference to EGFR (drives) (diagram)

CDK

2026-07-20T22:10:56Z

Technobaboo: Add inference to Cell Division (drives) (diagram)

{{#inference:id=1|to=Cell Division|tag=drives}}

[[Category:Kinase]]

Cyclin

2026-07-20T22:10:47Z

Technobaboo: Add inference to CDK (activates) (diagram)

{{#inference:id=1|to=CDK|tag=activates}}

[[Category:Regulatory Protein]]

Diagram:Map

2026-07-20T22:10:37Z

Technobaboo: Add "Cell Division" to the diagram

{
"version": 2,
"allPages": true,
"category": "",
"pages": [
"ERα",
"ERβ",
"IGF-1",
"E2",
"T",
"Aromatase",
"IGF-1R",
"GR",
"Clobetasol",
"Dexras1",
"MAPK",
"PPAR-γ",
"Pioglitazone",
"CBD",
"FOXA1",
"GATA3",
"Breast Ductal Lengthening",
"EGFR",
"AREG",
"PI3K",
"Akt",
"CDK",
"Cyclin",
"Cell Division"
],
"view": {
"x": 1615.94,
"y": -516.78,
"zoom": 2.5
},
"things": {
"AREG": {
"x": 469.96,
"y": -358.6,
"pinned": false
},
"Aromatase": {
"x": 54.08,
"y": -84,
"pinned": false
},
"Breast Ductal Lengthening": {
"x": 1421.19,
"y": -358.41,
"pinned": false
},
"CBD": {
"x": -216.95,
"y": -759.79,
"pinned": false
},
"Clobetasol": {
"x": -451.58,
"y": -511.67,
"pinned": false
},
"Dexras1": {
"x": 69.67,
"y": -506.79,
"pinned": false
},
"E2": {
"x": 175.3,
"y": -206.56,
"pinned": false
},
"EGFR": {
"x": 725.07,
"y": -360.59,
"pinned": false
},
"ERα": {
"x": 177.48,
"y": -356.62,
"pinned": false
},
"ERβ": {
"x": 174.23,
"y": -69.74,
"pinned": false
},
"FOXA1": {
"x": 550.77,
"y": -248.41,
"pinned": false
},
"GATA3": {
"x": 669.67,
"y": -246.7,
"pinned": false
},
"GR": {
"x": -218.11,
"y": -508.12,
"pinned": false
},
"IGF-1": {
"x": -377.56,
"y": -379.15,
"pinned": false
},
"IGF-1R": {
"x": -221.29,
"y": -381.29,
"pinned": false
},
"MAPK": {
"x": -33.87,
"y": -368.8,
"pinned": false
},
"Main Page": {
"x": -446.18,
"y": -780.94,
"pinned": false
},
"PPAR-γ": {
"x": -221.04,
"y": -605.44,
"pinned": false
},
"Pioglitazone": {
"x": -448.49,
"y": -608.03,
"pinned": false
},
"T": {
"x": -71.89,
"y": -196.58,
"pinned": false
},
"PI3K": {
"x": 905.34,
"y": -530.41,
"pinned": false
},
"Akt": {
"x": 1184.94,
"y": -537.21,
"pinned": false
},
"CDK": {
"x": 1685.74,
"y": -533.61,
"pinned": false
},
"Cyclin": {
"x": 1362.54,
"y": -536.81,
"pinned": false
},
"Cell Division": {
"x": 1557.34,
"y": -550.01,
"pinned": false
}
},
"edges": {
"E2#1": {
"hx": 177.25,
"hy": -259.7,
"hset": true,
"pinned": false
},
"E2#2": {
"hx": 169.85,
"hy": -136.69,
"hset": true,
"pinned": false
},
"ERβ#1": {
"hx": 317.05,
"hy": -215.89,
"hset": true,
"pinned": false
},
"MAPK#2": {
"hx": 19.97,
"hy": -294.75,
"hset": true,
"pinned": false
}
}
}

Cell Division

2026-07-20T22:10:37Z

Technobaboo: Create page from diagram Diagram:Map

Akt

2026-07-20T22:10:16Z

Technobaboo: Add inference to Cyclin (activates) (diagram)

{{#inference:id=1|to=Cyclin|tag=activates}}

[[Category:Kinase]]

Cyclin

2026-07-20T22:10:01Z

Technobaboo: Set type to Regulatory Protein (diagram)

[[Category:Regulatory Protein]]

Category:Regulatory Protein

2026-07-20T22:10:01Z

Technobaboo: Mark category as an Inferences thing type

Cyclin

2026-07-20T22:09:02Z

Technobaboo: Set type to Kinase (diagram)

[[Category:Kinase]]

Diagram:Map

2026-07-20T22:09:00Z

Technobaboo: Add "Cyclin" to the diagram

{
"version": 2,
"allPages": true,
"category": "",
"pages": [
"ERα",
"ERβ",
"IGF-1",
"E2",
"T",
"Aromatase",
"IGF-1R",
"GR",
"Clobetasol",
"Dexras1",
"MAPK",
"PPAR-γ",
"Pioglitazone",
"CBD",
"FOXA1",
"GATA3",
"Breast Ductal Lengthening",
"EGFR",
"AREG",
"PI3K",
"Akt",
"CDK",
"Cyclin"
],
"view": {
"x": 1306.74,
"y": -521.98,
"zoom": 2.5
},
"things": {
"AREG": {
"x": 469.96,
"y": -358.6,
"pinned": false
},
"Aromatase": {
"x": 54.08,
"y": -84,
"pinned": false
},
"Breast Ductal Lengthening": {
"x": 1421.19,
"y": -358.41,
"pinned": false
},
"CBD": {
"x": -216.95,
"y": -759.79,
"pinned": false
},
"Clobetasol": {
"x": -451.58,
"y": -511.67,
"pinned": false
},
"Dexras1": {
"x": 69.67,
"y": -506.79,
"pinned": false
},
"E2": {
"x": 175.3,
"y": -206.56,
"pinned": false
},
"EGFR": {
"x": 725.07,
"y": -360.59,
"pinned": false
},
"ERα": {
"x": 177.48,
"y": -356.62,
"pinned": false
},
"ERβ": {
"x": 174.23,
"y": -69.74,
"pinned": false
},
"FOXA1": {
"x": 550.77,
"y": -248.41,
"pinned": false
},
"GATA3": {
"x": 669.67,
"y": -246.7,
"pinned": false
},
"GR": {
"x": -218.11,
"y": -508.12,
"pinned": false
},
"IGF-1": {
"x": -377.56,
"y": -379.15,
"pinned": false
},
"IGF-1R": {
"x": -221.29,
"y": -381.29,
"pinned": false
},
"MAPK": {
"x": -33.87,
"y": -368.8,
"pinned": false
},
"Main Page": {
"x": -446.18,
"y": -780.94,
"pinned": false
},
"PPAR-γ": {
"x": -221.04,
"y": -605.44,
"pinned": false
},
"Pioglitazone": {
"x": -448.49,
"y": -608.03,
"pinned": false
},
"T": {
"x": -71.89,
"y": -196.58,
"pinned": false
},
"PI3K": {
"x": 905.34,
"y": -530.41,
"pinned": false
},
"Akt": {
"x": 1184.94,
"y": -537.21,
"pinned": false
},
"CDK": {
"x": 1523.74,
"y": -520.01,
"pinned": false
},
"Cyclin": {
"x": 1362.94,
"y": -565.21,
"pinned": false
}
},
"edges": {
"E2#1": {
"hx": 177.25,
"hy": -259.7,
"hset": true,
"pinned": false
},
"E2#2": {
"hx": 169.85,
"hy": -136.69,
"hset": true,
"pinned": false
},
"ERβ#1": {
"hx": 317.05,
"hy": -215.89,
"hset": true,
"pinned": false
},
"MAPK#2": {
"hx": 19.97,
"hy": -294.75,
"hset": true,
"pinned": false
}
}
}

Cyclin

2026-07-20T22:08:59Z

Technobaboo: Create page from diagram Diagram:Map

CDK

2026-07-20T22:08:47Z

Technobaboo: Set type to Kinase (diagram)

[[Category:Kinase]]

Diagram:Map

2026-07-20T22:08:45Z

Technobaboo: Add "CDK" to the diagram

{
"version": 2,
"allPages": true,
"category": "",
"pages": [
"ERα",
"ERβ",
"IGF-1",
"E2",
"T",
"Aromatase",
"IGF-1R",
"GR",
"Clobetasol",
"Dexras1",
"MAPK",
"PPAR-γ",
"Pioglitazone",
"CBD",
"FOXA1",
"GATA3",
"Breast Ductal Lengthening",
"EGFR",
"AREG",
"PI3K",
"Akt",
"CDK"
],
"view": {
"x": 1129.54,
"y": -443.18,
"zoom": 2.5
},
"things": {
"AREG": {
"x": 469.96,
"y": -358.6,
"pinned": false
},
"Aromatase": {
"x": 54.08,
"y": -84,
"pinned": false
},
"Breast Ductal Lengthening": {
"x": 1421.19,
"y": -358.41,
"pinned": false
},
"CBD": {
"x": -216.95,
"y": -759.79,
"pinned": false
},
"Clobetasol": {
"x": -451.58,
"y": -511.67,
"pinned": false
},
"Dexras1": {
"x": 69.67,
"y": -506.79,
"pinned": false
},
"E2": {
"x": 175.3,
"y": -206.56,
"pinned": false
},
"EGFR": {
"x": 725.07,
"y": -360.59,
"pinned": false
},
"ERα": {
"x": 177.48,
"y": -356.62,
"pinned": false
},
"ERβ": {
"x": 174.23,
"y": -69.74,
"pinned": false
},
"FOXA1": {
"x": 550.77,
"y": -248.41,
"pinned": false
},
"GATA3": {
"x": 669.67,
"y": -246.7,
"pinned": false
},
"GR": {
"x": -218.11,
"y": -508.12,
"pinned": false
},
"IGF-1": {
"x": -377.56,
"y": -379.15,
"pinned": false
},
"IGF-1R": {
"x": -221.29,
"y": -381.29,
"pinned": false
},
"MAPK": {
"x": -33.87,
"y": -368.8,
"pinned": false
},
"Main Page": {
"x": -446.18,
"y": -780.94,
"pinned": false
},
"PPAR-γ": {
"x": -221.04,
"y": -605.44,
"pinned": false
},
"Pioglitazone": {
"x": -448.49,
"y": -608.03,
"pinned": false
},
"T": {
"x": -71.89,
"y": -196.58,
"pinned": false
},
"PI3K": {
"x": 905.34,
"y": -530.41,
"pinned": false
},
"Akt": {
"x": 1184.94,
"y": -537.21,
"pinned": false
},
"CDK": {
"x": 1333.74,
"y": -520.41,
"pinned": false
}
},
"edges": {
"E2#1": {
"hx": 177.25,
"hy": -259.7,
"hset": true,
"pinned": false
},
"E2#2": {
"hx": 169.85,
"hy": -136.69,
"hset": true,
"pinned": false
},
"ERβ#1": {
"hx": 317.05,
"hy": -215.89,
"hset": true,
"pinned": false
},
"MAPK#2": {
"hx": 19.97,
"hy": -294.75,
"hset": true,
"pinned": false
}
}
}

CDK

2026-07-20T22:08:45Z

Technobaboo: Create page from diagram Diagram:Map

EGFR

2026-07-20T22:06:24Z

Technobaboo: Update inference §2 (diagram)

{{#inference:id=1|to=Breast Ductal Lengthening|tag=facilitates}}<ref>{{cite web|url=https://doi.org/10.1073/pnas.0611647104|title=Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development|author=Laura Ciarloni; Sonia Mallepell; Cathrin Brisken|date=2007|quote=In fact, we find that estrogens induce amphiregulin through the ERα and require amphiregulin to induce proliferation of the mammary epithelium.}}</ref>

== References ==
<references />

{{#inference:id=2|to=PI3K|tag=activates|context=intracellular}}

[[Category:Receptor]]

EGFR

2026-07-20T22:06:19Z

Technobaboo: Add inference to PI3K (activates) (diagram)

PI3K

2026-07-20T22:06:07Z

Technobaboo: Update inference §1 (diagram)

{{#inference:id=1|to=Akt|tag=activates|context=intracellular}}

[[Category:Kinase]]

PI3K

2026-07-20T22:06:03Z

Technobaboo: Add inference to Akt (activates) (diagram)

{{#inference:id=1|to=Akt|tag=activates}}

[[Category:Kinase]]

Akt

2026-07-20T22:05:49Z

Technobaboo: Set type to Kinase (diagram)

[[Category:Kinase]]

Diagram:Map

2026-07-20T22:05:47Z

Technobaboo: Add "Akt" to the diagram

{
"version": 2,
"allPages": true,
"category": "",
"pages": [
"ERα",
"ERβ",
"IGF-1",
"E2",
"T",
"Aromatase",
"IGF-1R",
"GR",
"Clobetasol",
"Dexras1",
"MAPK",
"PPAR-γ",
"Pioglitazone",
"CBD",
"FOXA1",
"GATA3",
"Breast Ductal Lengthening",
"EGFR",
"AREG",
"PI3K",
"Akt"
],
"view": {
"x": 988.34,
"y": -479.18,
"zoom": 2.5
},
"things": {
"AREG": {
"x": 469.96,
"y": -358.6,
"pinned": false
},
"Aromatase": {
"x": 54.08,
"y": -84,
"pinned": false
},
"Breast Ductal Lengthening": {
"x": 1215.59,
"y": -366.81,
"pinned": false
},
"CBD": {
"x": -216.95,
"y": -759.79,
"pinned": false
},
"Clobetasol": {
"x": -451.58,
"y": -511.67,
"pinned": false
},
"Dexras1": {
"x": 69.67,
"y": -506.79,
"pinned": false
},
"E2": {
"x": 175.3,
"y": -206.56,
"pinned": false
},
"EGFR": {
"x": 725.07,
"y": -360.59,
"pinned": false
},
"ERα": {
"x": 177.48,
"y": -356.62,
"pinned": false
},
"ERβ": {
"x": 174.23,
"y": -69.74,
"pinned": false
},
"FOXA1": {
"x": 550.77,
"y": -248.41,
"pinned": false
},
"GATA3": {
"x": 669.67,
"y": -246.7,
"pinned": false
},
"GR": {
"x": -218.11,
"y": -508.12,
"pinned": false
},
"IGF-1": {
"x": -377.56,
"y": -379.15,
"pinned": false
},
"IGF-1R": {
"x": -221.29,
"y": -381.29,
"pinned": false
},
"MAPK": {
"x": -33.87,
"y": -368.8,
"pinned": false
},
"Main Page": {
"x": -446.18,
"y": -780.94,
"pinned": false
},
"PPAR-γ": {
"x": -221.04,
"y": -605.44,
"pinned": false
},
"Pioglitazone": {
"x": -448.49,
"y": -608.03,
"pinned": false
},
"T": {
"x": -71.89,
"y": -196.58,
"pinned": false
},
"PI3K": {
"x": 978.54,
"y": -508.81,
"pinned": false
},
"Akt": {
"x": 1082.94,
"y": -527.21,
"pinned": false
}
},
"edges": {
"E2#1": {
"hx": 177.25,
"hy": -259.7,
"hset": true,
"pinned": false
},
"E2#2": {
"hx": 169.85,
"hy": -136.69,
"hset": true,
"pinned": false
},
"ERβ#1": {
"hx": 317.05,
"hy": -215.89,
"hset": true,
"pinned": false
},
"MAPK#2": {
"hx": 19.97,
"hy": -294.75,
"hset": true,
"pinned": false
}
}
}

Akt

2026-07-20T22:05:47Z

Technobaboo: Create page from diagram Diagram:Map

PI3K

2026-07-20T22:04:05Z

Technobaboo: Set type to Kinase (diagram)

[[Category:Kinase]]

Diagram:Map

2026-07-20T22:04:03Z

Technobaboo: Add "PI3K" to the diagram

{
"version": 2,
"allPages": true,
"category": "",
"pages": [
"ERα",
"ERβ",
"IGF-1",
"E2",
"T",
"Aromatase",
"IGF-1R",
"GR",
"Clobetasol",
"Dexras1",
"MAPK",
"PPAR-γ",
"Pioglitazone",
"CBD",
"FOXA1",
"GATA3",
"Breast Ductal Lengthening",
"EGFR",
"AREG",
"PI3K"
],
"view": {
"x": 854.34,
"y": -405.18,
"zoom": 2.5
},
"things": {
"AREG": {
"x": 469.96,
"y": -358.6,
"pinned": false
},
"Aromatase": {
"x": 54.08,
"y": -84,
"pinned": false
},
"Breast Ductal Lengthening": {
"x": 924.79,
"y": -362.41,
"pinned": false
},
"CBD": {
"x": -216.95,
"y": -759.79,
"pinned": false
},
"Clobetasol": {
"x": -451.58,
"y": -511.67,
"pinned": false
},
"Dexras1": {
"x": 69.67,
"y": -506.79,
"pinned": false
},
"E2": {
"x": 175.3,
"y": -206.56,
"pinned": false
},
"EGFR": {
"x": 725.07,
"y": -360.59,
"pinned": false
},
"ERα": {
"x": 177.48,
"y": -356.62,
"pinned": false
},
"ERβ": {
"x": 174.23,
"y": -69.74,
"pinned": false
},
"FOXA1": {
"x": 550.77,
"y": -248.41,
"pinned": false
},
"GATA3": {
"x": 669.67,
"y": -246.7,
"pinned": false
},
"GR": {
"x": -218.11,
"y": -508.12,
"pinned": false
},
"IGF-1": {
"x": -377.56,
"y": -379.15,
"pinned": false
},
"IGF-1R": {
"x": -221.29,
"y": -381.29,
"pinned": false
},
"MAPK": {
"x": -33.87,
"y": -368.8,
"pinned": false
},
"Main Page": {
"x": -446.18,
"y": -780.94,
"pinned": false
},
"PPAR-γ": {
"x": -221.04,
"y": -605.44,
"pinned": false
},
"Pioglitazone": {
"x": -448.49,
"y": -608.03,
"pinned": false
},
"T": {
"x": -71.89,
"y": -196.58,
"pinned": false
},
"PI3K": {
"x": 819.34,
"y": -495.21,
"pinned": false
}
},
"edges": {
"E2#1": {
"hx": 177.25,
"hy": -259.7,
"hset": true,
"pinned": false
},
"E2#2": {
"hx": 169.85,
"hy": -136.69,
"hset": true,
"pinned": false
},
"ERβ#1": {
"hx": 317.05,
"hy": -215.89,
"hset": true,
"pinned": false
},
"MAPK#2": {
"hx": 19.97,
"hy": -294.75,
"hset": true,
"pinned": false
}
}
}

PI3K

2026-07-20T22:04:03Z

Technobaboo: Create page from diagram Diagram:Map

ERβ

2026-07-20T21:33:18Z

Technobaboo: Update inference §1 (diagram)

{{#inference:id=1|to=ERα|tag=inhibits}}

[[Category:Receptor]]
aka Estrogen Receptor Beta

see https://en.wikipedia.org/wiki/Estrogen_receptor_beta

Diagram:Map

2026-07-20T13:21:17Z

Technobaboo: Update diagram layout

{
"version": 2,
"allPages": true,
"category": "",
"pages": [
"ERα",
"ERβ",
"IGF-1",
"E2",
"T",
"Aromatase",
"IGF-1R",
"GR",
"Clobetasol",
"Dexras1",
"MAPK",
"PPAR-γ",
"Pioglitazone",
"CBD",
"FOXA1",
"GATA3",
"Breast Ductal Lengthening",
"EGFR",
"AREG"
],
"view": {
"x": 557.3,
"y": -305.98,
"zoom": 1.776
},
"things": {
"AREG": {
"x": 469.96,
"y": -358.6,
"pinned": false
},
"Aromatase": {
"x": 54.08,
"y": -84,
"pinned": false
},
"Breast Ductal Lengthening": {
"x": 924.79,
"y": -362.41,
"pinned": false
},
"CBD": {
"x": -216.95,
"y": -759.79,
"pinned": false
},
"Clobetasol": {
"x": -451.58,
"y": -511.67,
"pinned": false
},
"Dexras1": {
"x": 69.67,
"y": -506.79,
"pinned": false
},
"E2": {
"x": 175.3,
"y": -206.56,
"pinned": false
},
"EGFR": {
"x": 725.07,
"y": -360.59,
"pinned": false
},
"ERα": {
"x": 177.48,
"y": -356.62,
"pinned": false
},
"ERβ": {
"x": 174.23,
"y": -69.74,
"pinned": false
},
"FOXA1": {
"x": 550.77,
"y": -248.41,
"pinned": false
},
"GATA3": {
"x": 669.67,
"y": -246.7,
"pinned": false
},
"GR": {
"x": -218.11,
"y": -508.12,
"pinned": false
},
"IGF-1": {
"x": -377.56,
"y": -379.15,
"pinned": false
},
"IGF-1R": {
"x": -221.29,
"y": -381.29,
"pinned": false
},
"MAPK": {
"x": -33.87,
"y": -368.8,
"pinned": false
},
"Main Page": {
"x": -446.18,
"y": -780.94,
"pinned": false
},
"PPAR-γ": {
"x": -221.04,
"y": -605.44,
"pinned": false
},
"Pioglitazone": {
"x": -448.49,
"y": -608.03,
"pinned": false
},
"T": {
"x": -71.89,
"y": -196.58,
"pinned": false
}
},
"edges": {
"E2#1": {
"hx": 177.25,
"hy": -259.7,
"hset": true,
"pinned": false
},
"E2#2": {
"hx": 169.85,
"hy": -136.69,
"hset": true,
"pinned": false
},
"ERβ#1": {
"hx": 317.05,
"hy": -215.89,
"hset": true,
"pinned": false
},
"MAPK#2": {
"hx": 19.97,
"hy": -294.75,
"hset": true,
"pinned": false
}
}
}

MAPK

2026-07-20T13:11:32Z

Technobaboo: Update inference §2 (diagram)

{{#inference:id=1|to=ERα|tag=phosphorylates}}

{{#inference:id=2|to=ERβ|tag=phosphorylates}}<ref>{{cite web
|title=Estrogen receptor beta growth-inhibitory effects are repressed through activation of MAPK and PI3K signalling in mammary epithelial and breast cancer cells
|author=Cotrim, C Z; Fabris, V; Doria, M L; Lindberg, K; Gustafsson, J-Å; Amado, F; Lanari, C; Helguero, L A
|date=2013/05
|publisher=Oncogene
|url=https://www.nature.com/articles/onc2012261
|doi=10.1038/onc.2012.261
|quote=
}}</ref>

== References ==
<references />

[[Category:Kinase]]

MAPK

2026-07-20T13:11:24Z

Technobaboo: Add inference to ERβ (phosphorylates) (diagram)

{{#inference:id=1|to=ERα|tag=phosphorylates}}

{{#inference:id=2|to=ERβ|tag=phosphorylates}}

[[Category:Kinase]]

E2

2026-07-20T13:07:19Z

Technobaboo: Update inference §2 (diagram)

aka Estradiol

{{#inference:id=1|to=ERα|tag=activates|context=strongly}}

{{#inference:id=2|to=ERβ|tag=activates|context=strongly}}

See https://en.wikipedia.org/wiki/Estradiol
[[Category:Ligand]]

E2

2026-07-20T13:07:13Z

Technobaboo: Update inference §1 (diagram)

aka Estradiol

{{#inference:id=1|to=ERα|tag=activates|context=strongly}}

{{#inference:id=2|to=ERβ|tag=activates}}

See https://en.wikipedia.org/wiki/Estradiol
[[Category:Ligand]]

AREG

2026-07-20T13:05:10Z

Technobaboo: Update inference §1 (diagram)

{{#inference:id=1|to=EGFR|tag=activates|context=paracrine}}<ref>{{cite web|url=https://doi.org/10.1073/pnas.0611647104|title=Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development|author=Laura Ciarloni; Sonia Mallepell; Cathrin Brisken|date=2007|quote=In fact, we find that estrogens induce amphiregulin through the ERα and require amphiregulin to induce proliferation of the mammary epithelium.}}</ref>

== References ==
<references />

[[Category:Growth Factor]]