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Technobaboo (talk | contribs) Update inference §2 (diagram) |
Technobaboo (talk | contribs) Update inference §3 (diagram) |
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{{#inference:id= | {{#inference:id=3|to=CDK|tag=displaces ERα from|context=specifically CCND1/CDK2/CDK6, via FOXA1-primed chromatin sites}}<ref>{{cite web | ||
|title=Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. | |title=Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. | ||
|author=Tonsing-Carter E; Hernandez KM; Kim CR; Harkless RV; Oh A; Bowie KR; West-Szymanski DC; Betancourt-Ponce MA; Green BD; Lastra RR; Fleming GF; Chandarlapaty S; Conzen SD | |author=Tonsing-Carter E; Hernandez KM; Kim CR; Harkless RV; Oh A; Bowie KR; West-Szymanski DC; Betancourt-Ponce MA; Green BD; Lastra RR; Fleming GF; Chandarlapaty S; Conzen SD | ||
Latest revision as of 22:57, 20 July 2026
→ induces expression of Dexras1[1]
References
- ↑ Hyo Jung Kim, et al.."Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis".
Previously, we showed that small G protein Dexras1 is expressed by glucocorticoids and leads to adipocyte differentiation
→ displaces ERα from CDK (specifically CCND1/CDK2/CDK6, via FOXA1-primed chromatin sites)[1]
- ↑ Tonsing-Carter E; Hernandez KM; Kim CR; Harkless RV; Oh A; Bowie KR; West-Szymanski DC; Betancourt-Ponce MA; Green BD; Lastra RR; Fleming GF; Chandarlapaty S; Conzen SD."Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.".