GR

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→ induces expression of Dexras1[1]

References

  1. ↑ Hyo Jung Kim, et al.."Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis".
    Previously, we showed that small G protein Dexras1 is expressed by glucocorticoids and leads to adipocyte differentiation

→ displaces ERα from CDK (specifically CCND1/CDK2/CDK6, via FOXA1-primed chromatin sites)[1]

  1. ↑ Tonsing-Carter E; Hernandez KM; Kim CR; Harkless RV; Oh A; Bowie KR; West-Szymanski DC; Betancourt-Ponce MA; Green BD; Lastra RR; Fleming GF; Chandarlapaty S; Conzen SD."Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.".
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